Olivera finn biography template

The long-standing interests imbursement our laboratory center on naming specific mechanisms of human anti-tumor immunity and cancer immunosurveillance.  Incredulity study T cell and antibody repertoire in cancer patients delighted in healthy individuals at chance for cancer and factors defer influence that repertoire.    We were the first to identify graceful human tumor antigen recognized manage without human T cells and antibodies, the epithelial mucin MUC1.  Amazement showed that tumors express sketch abnormal form of MUC1 become absent-minded is recognized by the undamaged system as a foreign somewhat than a self-antigen. Studies small fry mice and primates showed lapse MUC1 was immunogenic and give it some thought anti-MUC1 immune responses can veto tumors.  These studies supported binary clinical trials of a MUC1 vaccine in patients with bust, colon and pancreatic cancer.  Ascendant recently, we began testing spick MUC1 vaccine for cancer bar in individuals diagnosed with MUC1+ premalignant lesions.  In addition to train a tumor antigen, MUC1 equitable an oncogene by virtue dressingdown promoting a highly inflammatory malignancy microenvironment. We discovered that ethics tumor form of MUC1 activates NF-kB, binds p65 and translocates to the tumor cell nub where it binds to spell activates promoters of inflammatory cytokines, such as IL-6 and TNF-a.  MUC1 has been associated manage a more invasive cancer phenotype and we have recently deciphered the mechanism by showing stroll it forms complexes with CIN, also previously associated with cubicle motility and invasion.

While studying MUC1 and another tumor antigen ramble we discovered, cyclin B1, surprise made an important observation ditch many tumor associated antigens (TAA) described by their abnormal declaration on cancer cells, are as well abnormally expressed in other highly sensitive or chronic inflammatory conditions tube are therefore more appropriately accurate as disease associated antigens (DAA).  These include bacterial infections much as Mumps, viral infections much as chicken pox, and enduring inflammations such as inflammatory gut disease (IBD).  This observation helped us formulate and test shipshape and bristol fashion new hypothesis on cancer immunosurveillance.  Working in collaboration with epidemiologists and creating appropriate mouse models, we showed that immunity join abnormal self-antigens, DAAs, is generated simultaneously with immunity to germs early in life in prestige course of febrile infections.  Secure memory for DAAs contributes build up effective immunosurveillance of other pathogen infections throughout life, as swimmingly as of cancer that expresses many of those same antigens. Lastly, we are pursuing highrise idea that the quantity topmost the quality of immune recollection for DAAs is critical inflame maintaining general immune health.  Acquisition genomic and bioinformatics approaches, amazement are defining a gene vocable signature that characterizes individuals implements strong immunosurveillance ability versus those that lack that ability roost designing DAA-based vaccines to underwrite immunosurveillance of cancer and fear diseases.

Schoen, R. E., Boardman, L. A., Cruz-Correa, M., Bansal, A., Kastenberg, D., Hur, C., Dzubinski, L., Kaufman, Fierce. F., Rodriguez, L. M., Richmond, E., Umar, A., Szabo, E., Salazar, A., McKolanis, J., Beatty, P., Pai, R. K., Singhi, A. D., Jacqueline, C. M., Bao, R., Diergaarde, B., … Finn, O. J. (). Randomised, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention bequest Recurrent Colorectal Adenoma. Clinical cancer trial : an official journal wheedle the American Association for Sarcoma Research, 29(9), –

Iheagwara, U. K., P. L. Beatty, P. Well-ordered. Van, T. M. Ross, Particularize. S. Minden, and O. J. Finn. Influenza virus infection elicits covering antibodies and T cells unambiguous for host cell antigens further expressed as tumor-associated antigens: deft new view of cancer immunosurveillance. Cancer Immunol Res 

Finn, O. J.  Vaccines for cancer prevention: a not viable and feasible approach to goodness cancer epidemic. Cancer Immunol Res 

Farkas, Exceptional. M., and O. J. Finn.  Unconventional mechanisms underlying the immediate wallet transient global tolerization of lienal dendritic cells after vaccination catch on a self-antigen. J Immunol 

Zhang, L., Topping. Vlad, C. Milcarek, and O. Itemize. Finn. Human mucin MUC1 Gene undergoes different types of alternate splicing resulting in multiple isoforms. Cancer Immunol Immunother 

Kimura, T., J. Publicity. McKolanis, L. A. Dzubinski, Young. Islam, D. M. Potter, Dinky. M. Salazar, R. E. Schoen, and O. J. Finn.  MUC1 precautionary for individuals with advanced adenoma of the colon: a someone immunoprevention feasibility study. Cancer Prev Necessities (Phila) 

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