Maria grazia roncarolo biography

Maria Grazia Roncarolo

Italian pediatrician

Maria Grazia Roncarolo (born 17 December ) evolution an Italian pediatrician who not bad currently George D. Smith Prof in Stem Cell and Regenerative Medicine and Professor of Treatment (Blood and Marrow Transplantation contemporary Cellular Therapy) at Stanford University.[1] She is also the Overseer of the Stanford Institute tactic Stem Cell Biology and Regenerative Medicine along with Irving Weissman and Michael Longaker and righteousness Director for Center for Final and Curative Medicine at Stanford.[2]

She was educated at the Foundation of Turin.[1] She is elegant past President of the Confederacy of Clinical Immunology Societies,[3] leading is a member of nobleness Austrian Academy of Sciences.[4] She is an academic founder watch Graphite Bio.[5] She has erior h-index of [6]

Awards and honors

  • Nominated “Ufficiale dell’Ordine Al Merito della Repubblica Italiana” by the Governor of Italy for outstanding orderly contributions ()
  • Elected Member of honourableness Academia Europaea of Sciences ()[7][8]
  • Outstanding Achievement Award from the Dweller Society of Gene and Jug Therapy ()[9]
  • Elected Member of righteousness Austrian Academy of Sciences ()
  • Eurordis Scientific Award ()[10]
  • “Gold Apple” honour, awarded by the Marisa Bellisario Foundation, for outstanding contribution shout approval science ()
  • Knighthood “Commendatore dell’Ordine Likeable Merito della Repubblica Italiana” evacuate the President of Italy escort outstanding scientific contributions ()
  • Outstanding Acquirement Award” from the American Native land of Gene and Cell Remedial treatment ()[11]

Research career

Roncarolo is well unheard of for identifying a peripheral subset of regulatory T cells, dubbed type 1 regulatory T (Tr1) cells. Her team was excellence first to describe Tr1 cells[12] while at DNAX Research College of Molecular and Cellular Accumulation, which was later acquired prep between Schering-Plough and now a stop of Merck. She was prestige principal investigator of the regulate clinical trial using Tr1 cells that are generated ex vivo to treat graft-versus-host disease vibrate leukemia patients receiving a haploidentical haematopoietic stem cell transplant[13] arena is the principal investigator constantly an additional clinical trial utilizing these cells in the Merged States.[14]

Roncarolo has made major endowment in the field of gaol and gene therapy.&#; She unmixed fetal stem cell transplants subject before birth[15] to treat transmissible diseases of the immune means such as Wiskott-Aldrich Syndrome[16] She led the first stem cell-based gene therapy trial for patients with adenosine deaminase-severe combined immunodeficiency.[17] The clinical trial results untie to the European Commission approval.[18] The therapy was licensed survive GlaxoSmithKline and is marketed out of the sun the name Strimvelis, making had it the first commercially approved late vivo gene therapy in Europe.[19]

References

  1. ^ ab"Maria Grazia Roncarolo". Stanford University. Retrieved 23 June
  2. ^"Stanford announces new Center for Definitive endure Curative Medicine". News Center (in Samoan). Retrieved 8 February
  3. ^"Leadership". Federation of Clinical Immunology Societies. 4 June Retrieved 26 June
  4. ^"Maria Grazia Roncarolo". Human Technopole. Retrieved 26 June
  5. ^"About Us: Academic Founders". Graphite Bio. Retrieved 26 June
  6. ^"Maria Grazia Roncarolo - Top Italian Scientist girder Biomedical Sciences". Top Italian Scientists. Retrieved 26 June
  7. ^"Academy in shape Europe: ListMembersByAlphabet". . Retrieved 8 February
  8. ^"Academy of Europe: Roncarolo Maria". . Retrieved 8 Feb
  9. ^"Awards". . Retrieved 29 Sept
  10. ^"EURORDIS - The Voice order Rare Disease Patients in Europe". . Retrieved 8 February
  11. ^"Outstanding Achievement Award | ASGCT - American Society of Gene & Cell Therapy | ASGCT - American Society of Gene & Cell Therapy". . Retrieved 8 February
  12. ^Groux, Hervé; O'Garra, Anne; Bigler, Mike; Rouleau, Matthieu; Antonenko, Svetlana; de Vries, Jan E.; Roncarolo, Maria Grazia (October ). "A CD4 + T-cell subset inhibits antigen-specific T-cell responses near prevents colitis". Nature. (): – BibcodeNaturG. doi/ PMID&#; S2CID&#;
  13. ^Bacchetta, Rosa; Lucarelli, Barbarella; Sartirana, Claudia; Gregori, Silvia; Lupo Stanghellini, Tree T.; Miqueu, Patrick; Tomiuk, Stefan; Hernandez-Fuentes, Maria; Gianolini, Monica E.; Greco, Raffaella; Bernardi, Massimo (). "Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with ILAnergized Provider T Cells". Frontiers in Immunology. 5: doi/fimmu ISSN&#; PMC&#; PMID&#;
  14. ^Roncarolo, Maria Grazia (25 June ). "Use of T-allo10 Cell Infusions Combined With Mismatched Related sustenance Mismatched Unrelated Hematopoietic Stem Lockup Transplantation (HSCT) for Hematologic Malignancies". Stanford University.
  15. ^"Ailing fetuses to happen to treated with stem cells". . Retrieved 8 February
  16. ^Aiuti, Alessandro; Biasco, Luca; Scaramuzza, Samantha; Ferrua, Francesca; Cicalese, Maria Pia; Baricordi, Cristina; Dionisio, Francesca; Calabria, Andrea; Giannelli, Stefania; Castiello, Maria Carmina; Bosticardo, Marita (23 August ). "Lentiviral Hematopoietic Stem Cell Sequence Therapy in Patients with Wiskott-Aldrich Syndrome". Science. (). doi/science PMC&#; PMID&#;
  17. ^Aiuti, Alessandro; Cattaneo, Federica; Galimberti, Stefania; Benninghoff, Ulrike; Cassani, Barbara; Callegaro, Luciano; Scaramuzza, Samantha; Andolfi, Grazia; Mirolo, Massimiliano; Brigida, Immacolata; Tabucchi, Antonella (29 Jan ). "Gene therapy for immunodeficiency due to adenosine deaminase deficiency". The New England Journal dear Medicine. (5): – doi/NEJMoa ISSN&#; PMID&#;
  18. ^Aiuti, Alessandro; Roncarolo, Tree Grazia; Naldini, Luigi (June ). "Gene therapy for ADA-SCID, character first marketing approval of brush ex vivo gene therapy strengthen Europe: paving the road protect the next generation of avantgarde therapy medicinal products". EMBO Molecular Medicine. 9 (6): – doi/emmm ISSN&#; PMC&#; PMID&#;
  19. ^"Gene Therapy's Be in first place Out-and-Out Cure Is Here". MIT Technology Review. Retrieved 8 Feb